Scientific research about Essential fatty Acids
The Science behind Omega-6 and Omega-3
The Modern World Problem
The agriculture revolution together with processed and refined foods have dramatic increased our consumption of Omega-6. Omega-6 creates inflammation and the new norm is most people live with Chronic diseases in one form or the other.
Our bodies are designed to function at a Omega-6:3 balance below 3:1 but the extreme consumption of Omega-6 have changed to balance to 15:1 and above.
The BalanceOil from Zinzino will bring your Omega-6:3 Balance back to normal at 3:1 and below.
The western world diet
Several sources of information suggest that human being evolved on a diet with a ratio of Omega-6 to Omega-3 essential fatty acids of 1:1, where as in modern world diet the ratio is above 15:1. The modern world diet are deficient in Omega-3 fatty acids and have excessive amount of Omega-6.
"The importance of the ratio of Omega-6/Omega-3 essential fatty acids"
Excessive consumption of Omega-6 consequences
The health implication of a diet full of Omega 6 are multifold and with highly degrading health as a consequence. Chronic conditions such as Cardiovascular Disease and Atherosclerosis, diabetes, obesity, rheumatoid arthritis, and Inflammatory Bowel Disease are all associated with increased production of local hormones that increase with a diet high on Omega-6.
"Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids"
Why the Zinzino BalanceOil formula works
Clinical trials have been generating terrible results both for the fish oil industry, and all those who have been swallowing fish oil supplements. We have to look in another directing to find clear indication of Omega-3 benefits.
The Inuit diet – you can see right away that they ate a diet containing many more actives than are found in any fish oil capsule. One of those actives is one of the rare polyphenols that is soluble in oil and fat, and which is produced by the same cold water algae that produce the omega 3’s that are consumed by krill, fish, marine mammals and eventually the Inuit. This polyphenol is a treasure, as it is not only the best antioxidant for fish oils yet discovered, it is also a powerful anti-inflammatory compound in its own right.
To gain the Inuit’s freedom from degenerative disease, fish oil is not enough. But if you mix it with virgin olive oil containing oil-soluble polyphenols (thus combining the best of the Inuit and the Mediterranean diets), chronic inflammation is effectively stopped in its traces.
"Algal polyphenols as novel natural antioxidants"
Omega-6 and Omega-3 fatty Acids and the Inflammation Process
"Omega-3 Fatty Acids and Inflammatory Processes"
Long chain fatty acids influence inflammation through a variety of mechanisms; many of these are mediated by, or at least associated with, changes in fatty acid composition of cell membranes.
Changes in these compositions can modify membrane fluidity, cell signaling leading to altered gene expression, and the pattern of lipid mediator production.
Cell involved in the inflammatory response are typically rich in the n-6 fatty acid arachidonic acid, but the contents of arachidonic acid and of the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can be altered through oral administration of EPA and DHA. Eicosanoids produced from arachidonic acid have roles in inflammation.
EPA also gives rise to eicosanoids and these often have differing properties from those of arachidonic acid-derived eicosanoids. EPA and DHA give rise to newly discovered Resolvins which are anti-inflammatory and inflammation resolving. Increased membrane content of EPA and DHA (and decreased arachidonic acid content) results in a changed pattern of production of eicosanoids and resolvins.
Changing the fatty acid composition of cells involved in the inflammatory response also affects production of peptide mediators of inflammation (adhesion molecules, cytokines etc.). Thus, the fatty acid composition of cells involved in the inflammatory response influences their function; the contents of arachidonic acid, EPA and DHA appear to be especially important.
The anti-inflammatory effects of marine n-3 PUFAs suggest that they may be useful as therapeutic agents in disorders with an inflammatory component.
Where an inflammatory response does occur, it is normally well regulated in order that it does not cause excessive damage to the host, is self-limiting and resolves rapidly.
This self-regulating involves the activation of negative feedback mechanisms such as the secretion of anti-inflammatory mediators, inhibition of pro-inflammatory signaling cascades, shedding of receptors for inflammatory mediators, and activation of regulatory cells.
As such, when controlled properly, regulated inflammatory responses are essential to remain healthy and maintain homeostasis.
Pathological inflammation involves a loss of tolerance and/or of regulatory processes. Where this becomes excessive, irreparable damage to host tissues and disease can occur.
Resolvins: Novel Anti-Inflammatory and Inflammation Resolving Mediators Produced from EPA and DHA
EPA and DHA also give rise to Resolvins and related compounds (e.g., protectins) through pathways involving cyclooxygenase and lipoxygenase enzymes. These mediators have been demonstrated in cell culture and animal feeding studies to be anti-inflammatory and inflammation resolving.
The role of Resolvins and related compounds may be very important because resolution of inflammation is important in shutting off the ongoing inflammatory process and in limiting tissue damage.
Resolvins could be an important factor to treat Covid 19 disease
"Omega-3's to Stay Healthy and Avoid the Cytokine Storm of Covid-19"
Resolvins are lipid mediators derived from omega-3 fatty acids and serve as the body’s natural “stop” signals to inflammation. These medical researchers found that increasing levels of these resolvins or lipid mediators in the body could be a new therapeutic approach to preventing life-threatening inflammation caused by SARS-CoV-2.
The exciting part is that these lipid mediators that ‘turn off,’ or resolve, inflammation are already in clinical trials for other inflammation-driven diseases, such as eye disease, periodontal disease, and pain. The mediators can quickly be applied to turn off inflammation in COVID-19 patients. What makes resolvins ideal is that there are basically derived from omega-3 fatty acids that are already proven safe for human consumption, are inexpensive, easily available and consumed.
The most important thing about eicosanoids is to keep them in balance. These eicosanoids are totally controlled by the diet.